Perspective: the potential of pyrazole-based compounds in medicine
Identifieur interne : 001525 ( Main/Exploration ); précédent : 001524; suivant : 001526Perspective: the potential of pyrazole-based compounds in medicine
Auteurs : Frankline K. Keter [Afrique du Sud] ; James Darkwa [Afrique du Sud]Source :
- BioMetals [ 0966-0844 ] ; 2012-02-01.
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Abstract
Abstract: Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.
Url:
DOI: 10.1007/s10534-011-9496-4
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Keter</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Advanced Materials Division, Mintek, Private Bag X3015, 2125, Randburg</wicri:regionArea><wicri:noRegion>Randburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Afrique du Sud</country></affiliation></author><author><name sortKey="Darkwa, James" sort="Darkwa, James" uniqKey="Darkwa J" first="James" last="Darkwa">James Darkwa</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Chemistry, University of Johannesburg, Auckland Park Kingsway Campus, 2006, Auckland Park</wicri:regionArea><wicri:noRegion>Auckland Park</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">BioMetals</title><title level="j" type="sub">An International Journal on the Role of Metal Ions in Biology, Biochemistry and Medicine</title><title level="j" type="abbrev">Biometals</title><idno type="ISSN">0966-0844</idno><idno type="eISSN">1572-8773</idno><imprint><publisher>Springer Netherlands</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2012-02-01">2012-02-01</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="21">21</biblScope></imprint><idno type="ISSN">0966-0844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0966-0844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibacterial</term><term>Anticancer</term><term>Antiparasitic</term><term>Antiviral</term><term>Metal complexes</term><term>Pyrazole</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Keter, Frankline K" sort="Keter, Frankline K" uniqKey="Keter F" first="Frankline K." last="Keter">Frankline K. Keter</name></noRegion><name sortKey="Darkwa, James" sort="Darkwa, James" uniqKey="Darkwa J" first="James" last="Darkwa">James Darkwa</name><name sortKey="Keter, Frankline K" sort="Keter, Frankline K" uniqKey="Keter F" first="Frankline K." last="Keter">Frankline K. Keter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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